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Cellular & Molecular Biology Letters was founded in 1996 and transferred to BioMed Central in 2016. Previously, its publishers were Walter De Gruyter in 2015 (content available from De Gruyter's archive), and Springer from 2006–2014 (content available from BMC web page). Articles published between 1996 and 2005 can be found at, CMBL home page, the Volume List tab. To request free electronic versions of these articles, please contact

Thematic Series

Invited Papers

The papers in this collection were specially invited by the editors and represent work by leading researchers in their fields, as well the authors of the most cited papers from the previous issues of our journal (CMBL).

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  1. Mini review

    Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs

    Understanding the cellular pathways that regulate endothelial nitric oxide (eNOS, NOS3) expression and consequently nitric oxide (NO) bioavailability during hypoxia is a necessary aspect in the development of nov...

    Leszek Kalinowski, Anna Janaszak-Jasiecka, Anna Siekierzycka, Sylwia Bartoszewska, Marcin Woźniak, Dawid Lejnowski, James F. Collawn and Rafal Bartoszewski

    Cellular & Molecular Biology Letters 2016 21:16

    Published on: 6 September 2016

  2. Research article

    Changes in expression of cartilaginous genes during chondrogenesis of Wharton’s jelly mesenchymal stem cells on three-dimensional biodegradable poly(L-lactide-co-glycolide) scaffolds

    In cartilage tissue regeneration, it is important to develop biodegradable scaffolds that provide a structural and logistic template for three-dimensional cultures of chondrocytes. In this study, we evaluated ...

    Piotr Paduszyński, Ewelina Aleksander-Konert, Alicja Zajdel, Adam Wilczok, Katarzyna Jelonek, Andrzej Witek and Zofia Dzierżewicz

    Cellular & Molecular Biology Letters 2016 21:14

    Published on: 24 August 2016

  3. Mini review

    Nuclear and nucleolar activity of linker histone variant H1.0

    Histone H1.0 belongs to the class of linker histones (H1), although it is substantially distinct from other histone H1 family members. The differences can be observed in the chromosomal location and organizati...

    Andrzej Kowalski

    Cellular & Molecular Biology Letters 2016 21:15

    Published on: 24 August 2016

  4. Research article

    Effects of NH4CL application and removal on astrocytes and endothelial cells

    Hepatic encephalopathy (HE) is a complex disorder associated with increased ammonia levels in the brain. Although astrocytes are believed to be the principal cells affected in hyperammonemia (HA), endothelial ...

    Miha Bartolić, Andrej Vovk and Dušan Šuput

    Cellular & Molecular Biology Letters 2016 21:13

    Published on: 23 August 2016

  5. Short communication

    A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL

    This study focused on an extract from fermented flour from the Lady Joy variety of the common bean Phaseolus vulgaris. The extract, Lady Joy lysate (Lys LJ), is enriched in antioxidant compounds during the fermen...

    Morena Gabriele, Laura Pucci, Margherita La Marca, Daniela Lucchesi, Clara Maria Della Croce, Vincenzo Longo and Valter Lubrano

    Cellular & Molecular Biology Letters 2016 21:10

    Published on: 12 August 2016

  6. Research article

    In vitro chondrogenesis of Wharton’s jelly mesenchymal stem cells in hyaluronic acid-based hydrogels

    In this study, we evaluated the usefulness of two commercially available hyaluronic acid-based hydrogels, HyStem and HyStem-C, for the cultivation of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) and their ...

    Ewelina Aleksander-Konert, Piotr Paduszyński, Alicja Zajdel, Zofia Dzierżewicz and Adam Wilczok

    Cellular & Molecular Biology Letters 2016 21:11

    Published on: 12 August 2016

  7. Mini review

    Osteoporosis: the current status of mesenchymal stem cell-based therapy

    Osteoporosis, or bone loss, is a progressive, systemic skeletal disease that affects millions of people worldwide. Osteoporosis is generally age related, and it is underdiagnosed because it remains asymptomati...

    Jitrada Phetfong, Tanwarat Sanvoranart, Kuneerat Nartprayut, Natakarn Nimsanor, Kanokwan Seenprachawong, Virapong Prachayasittikul and Aungkura Supokawej

    Cellular & Molecular Biology Letters 2016 21:12

    Published on: 12 August 2016

  8. Short communication

    WNT5A–ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3

    Wnt5A, which is a member of the non-transforming Wnt protein family, is implicated in inflammatory processes. It is also highly expressed by ovarian cancer cells. ROR2, which is a member of the Ror-family of r...

    Somayeh Arabzadeh, Ghamartaj Hossein, Zahra Salehi-Dulabi and Amir Hassan Zarnani

    Cellular & Molecular Biology Letters 2016 21:9

    Published on: 28 July 2016

  9. Short communication

    Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma

    The prognosis for patients with esophageal cancer remains poor. Therefore, the identification of novel target molecules for the treatment of esophageal cancer is necessary. Here, we investigated the clinicopat...

    Hideyuki Ishiguro, Takehiro Wakasugi, Yukio Terashita, Nobuhiro Sakamoto, Tatsuya Tanaka, Hiroyuki Sagawa, Tomotaka Okubo and Hiromitsu Takeyama

    Cellular & Molecular Biology Letters 2016 21:5

    Published on: 28 July 2016

  10. Short communication

    The crucial role of miR-126 on suppressing progression of esophageal cancer by targeting VEGF-A

    miR-126 is a key regulator of oncogenic processes. It is functionally linked to cellular proliferation, survival and migration. Vascular endothelial growth factor A (VEGF-A), which is regarded as a tumorgenesi...

    Ranran Kong, Yuefeng Ma, Jie Feng, Shaomin Li, Wei Zhang, Jiantao Jiang, Jin Zhang, Zhe Qiao, Xiaoping Yang and Bin Zhou

    Cellular & Molecular Biology Letters 2016 21:3

    Published on: 28 July 2016

  11. Mini review

    Toll-like receptor 2 and type 2 diabetes

    Innate immunity plays a crucial role in the pathogenesis of type 2 diabetes and related complications. Since the toll-like receptors (TLRs) are central to innate immunity, it appears that they are important pa...

    Zahra Sepehri, Zohre Kiani, Ali Akbar Nasiri and Farhad Kohan

    Cellular & Molecular Biology Letters 2016 21:2

    Published on: 28 July 2016

  12. Short communication

    Identification of a novel deletion in the MMAA gene in two Iranian siblings with vitamin B12-responsive methylmalonic acidemia

    Adenosylcobalamin (vitamin B12) is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this enzyme are a cause of methylmalonic acidemia (MMA). Methylmalonic acidemia, cblA type, is an...

    Fatemeh Keyfi, Mohammad Reza Abbaszadegan, Arndt Rolfs, Slobodanka Orolicki, Morteza Moghaddassian and Abdolreza Varasteh

    Cellular & Molecular Biology Letters 2016 21:4

    Published on: 28 July 2016

  13. Mini review

    Regulation of phosphorus uptake and utilization: transitioning from current knowledge to practical strategies

    Phosphorus is a poorly bioavailable macronutrient that is essential for crop growth and yield. Overuse of phosphorus fertilizers results in low phosphorus use efficiency (PUE), has serious environmental conseq...

    Md. Mahmudul Hasan, Md. Mainul Hasan, Jaime A. Teixeira da Silva and Xuexian Li

    Cellular & Molecular Biology Letters 2016 21:7

    Published on: 28 July 2016

  14. Research article

    Effect of differentiation on microRNA expression in bovine skeletal muscle satellite cells by deep sequencing

    The differentiation of skeletal muscle-derived satellite cells (MDSCs) is important in controlling muscle growth, improving livestock muscle quality, and healing of muscle-related disease. MicroRNAs (miRNAs) a...

    Wei Wei Zhang, Xiao Feng Sun, Hui Li Tong, Ya Hui Wang, Shu Feng Li, Yun Qin Yan and Guang Peng Li

    Cellular & Molecular Biology Letters 2016 21:8

    Published on: 28 July 2016

  15. Review

    Natural antisense RNAs as mRNA regulatory elements in bacteria: a review on function and applications

    Naturally occurring antisense RNAs are small, diffusible, untranslated transcripts that pair to target RNAs at specific regions of complementarity to control their biological function by regulating gene expres...

    Fatemeh Saberi, Mehdi Kamali, Ali Najafi, Alavieh Yazdanparast and Mehrdad Moosazadeh Moghaddam

    Cellular & Molecular Biology Letters 2016 21:6

    Published on: 28 July 2016

  16. Short Communication

    Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells

    Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenes...

    Tamotsu Tsukahara, Hisao Haniu and Yoshikazu Matsuda

    Cellular & Molecular Biology Letters 2014 :224

    Published on: 17 December 2014

  17. Short Communication

    Identification of drought-induced transcription factors in Sorghum bicolor using GO term semantic similarity

    Stress tolerance in plants is a coordinated action of multiple stress response genes that also cross talk with other components of the stress signal transduction pathways. The expression and regulation of stre...

    Manoj Kumar Sekhwal, Ajit Kumar Swami, Vinay Sharma and Renu Sarin

    Cellular & Molecular Biology Letters 2014 :223

    Published on: 6 December 2014

  18. Short Communication

    Evaluation of the potential of alkylresorcinols as superoxide anion scavengers and sox-regulon modulators using nitroblue tetrazolium and bioluminescent cell-based assays

    The antioxidant activities of five alkylresorcinol (AR) homologs with alkyl chains of 1, 3, 5 6 and 12 carbon atoms were studied using molecular and cellular assays for superoxide anions ( ...

    Irina V. Gryazeva, Olga K. Davydova and Dmitrii G. Deryabin

    Cellular & Molecular Biology Letters 2014 :222

    Published on: 6 December 2014

  19. Short Communication

    Gene expression patterns in bone following lipopolysaccharide stimulation

    Bone displays suppressed osteogenesis in inflammatory diseases such as sepsis and rheumatoid arthritis. However, the underlying mechanisms have not yet been clearly explained. To identify the gene expression p...

    Jing Yang, Nan Su, Xiaolan Du and Lin Chen

    Cellular & Molecular Biology Letters 2014 19:216

    Published on: 29 October 2014

  20. Short Communication

    Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture

    The interstitial cells of Cajal (ICC) drive the slow wave-associated contractions in the small intestine. A commonly used marker for these cells is c-Kit, but another marker named Ano1 was recently described. Thi...

    Raúl Loera-Valencia, Xuan-Yu Wang, George W. J. Wright, Carlos Barajas-López and Jan D. Huizinga

    Cellular & Molecular Biology Letters 2014 19:214

    Published on: 23 October 2014

  21. Research Article

    Rapid proliferation of activated lymph node CD4+ T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression

    Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the...

    Takuya Mishima, Shoko Toda, Yoshiaki Ando, Tsukasa Matsunaga and Manabu Inobe

    Cellular & Molecular Biology Letters 2014 19:219

    Published on: 25 November 2014

  22. Short Communication

    Dysregulation of gene expression in ABCC6 knockdown HepG2 cells

    ABCC6 protein is an ATP-dependent transporter that is mainly found in the basolateral plasma membrane of hepatocytes. ABCC6 deficiency is the primary cause of several forms of ectopic mineralization syndrome. ...

    Rocchina Miglionico, Maria Francesca Armentano, Monica Carmosino, Antonella Maria Salvia, Flavia Cuviello, Faustino Bisaccia and Angela Ostuni

    Cellular & Molecular Biology Letters 2014 19:208

    Published on: 29 August 2014

  23. Short Communication

    Promoted megakaryocytic differentiation of K562 cells through oxidative stress caused by near ultraviolet irradiation

    Reactive oxygen species (ROS) have been proven to be important activators for various cellular activities, including cell differentiation. Several reports showed the necessity of ROS during cell differentiatio...

    Retno Wahyu Nurhayati, Yoshihiro Ojima, Naoki Nomura and Masahito Taya

    Cellular & Molecular Biology Letters 2014 19:215

    Published on: 23 October 2014

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