Fig. 6

Transcriptional activity of collagen type II, aggrecan, collagen type I, and collagen type III genes expressed as fold change in relation to control (expression = 1) in chondrocytes cultured for 21 days on: a 2D – monolayer, b 3D – PLGA scaffold. Control culture was carried out in growth medium in: a 2D – monolayer, b PLGA scaffold. Growth medium contained inter alia α-MEM medium with 10 % FBS. Chondrogenic medium contained inter alia differentiation factors such as dexamethasone and TGFβ3, ascorbic acid 2-phosphate, ITS + Premix, sodium pyruvate and 2 % FBS. * p < 0.05