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Table 1 The overview of intrinsic disorder features attributable to the mouse histone H1.0

From: Nuclear and nucleolar activity of linker histone variant H1.0

Physic-chemical and structural features Attributes of intrinsic disorder
Amino acid compositiona Enriched aa: Ala (14.9 %), Lys (28.9 %)
Depleted aa: Asp (2.1 %), Glu (2.6 %), Phe (1.1 %)
Grand average hydrophobicityb Negative (score −1.073)
Disorder degreec Ratio – 0.62; disordered aa – 120/whole aa – 194
Domain disorder levelc N- and C- – 100 %, Globular – 0 %
Long disordered regionsd Score – 0.8153, threshold score – 0.5380
MoRFs contente Three elements (6, 9 and 10 aa)
ANCHOR binding regionsf Seven elements (12, 11, 14, 9, 18, 6 and 55 aa)
Low-complexity regionsg 18 aa N-/86 aa C-
  1. aa amino acids, N (N-terminal), C (C-terminal), Globular histone H1.0 domains
  2. aComposition Profiler (Vacic et al. [63])
  3. bExPasy proteomic server (ProtParam, Gravy tool)
  4. cPrDOS (Ishida and Kinoshita [64])
  5. dSLIDER (Peng et al. [65])
  6. eMoRFpred (Disfani et al. [66])
  7. fANCHOR (Dosztànyi et al. [54])
  8. gSEG server (Wootton [67])