Fig. 1
From: Framework to function: mechanosensitive regulators of gene transcription
Schematic representation of the protein structure of the human myocardin-related transcription factor family. Various domains and motifs within the family members myocardin (MYOCD), myocardin-related transcriptional factor A (MRTF-A) and myocardin-related transcriptional factor B (MRTF-B) mediate specific functions: RPEL domain (purple) mediates cytoplasmic localisation and actin binding, basic (+; blue) and glutamine-rich (Q; burgundy) regions facilitate interaction with Serum Response Factor, whereas SAP domain (green) dictates promoter specificity. Leucine zipper (LZ; lime) mediates dimerization, and TAD (red) is a transcriptional activation domain. The PPxY motif (orange) mediates interaction with WW domains of partner proteins such as YAP. In MYOCD, PPSY is located at amino acid positions 768–771; in MRTF-A, PPGY is at amino acid positions 725–728; and in MRTF-B, PPRY is at amino acid positions 882–885. The number of amino acids for each protein is indicated