The regulatory mechanisms of NG2/CSPG4 expression

Table 1 Studies focusing on factors which regulate the expression of NG2/CSPG4

Regulatory factors / treatment		Species	Type of cells or tissue	Analysis	Expression	Reference
Inflammation	TNF-α, TGF-β, IL-1α or IFNγ	Rat	OPC	Protein	↑	[22]
	TGF-β	Mouse	Macrophages, OPC	mRNA, Protein	↑	[24]
	TGF-β	Rat	Cerebral cortex	Protein	↑	[25]
	Decorin	Rat	Spinal cord	Protein	↓	[26]
	TGF-β receptor inhibitor	Rat	Microglia cells	mRNA, Protein	↓	[28]
	LPS	Rat	Microglia cells	mRNA, Protein	↑	[23]
	IL11, LIF	Human	Placental villous tissue	mRNA, Protein	↑	[32]
	Chronic hypoxia (5 d)	Rat	Mesentery	Protein	↑	[35]
Hypoxia	Chronic hypoxia (48 h)	Human	Panc1, HS766T	mRNA, Protein	↑	[39]
DNA Methylation	Methyltransferase inhibitor (5-aza-2’-deoxycytidine)	Human	Melanoma cells	mRNA, Protein	↑	[45]
DNA Methylation	Methyltransferase inhibitor (5-aza-2’-deoxycytidine)	Human	Head and neck squamous cell carcinoma	mRNA, Protein	↑	[46]
Transcription factors	Truncated promoter constructs	Monkey	COS cells	Luciferase activity	↑	[49]
	Sp1 siRNA	Human	Keratinocytes	mRNA	↓	[50]
	Pax3	Human	Melanocytes, melanoma cells	mRNA	↑	[54]
	Pax3 siRNA	Human	Melanocytes, melanoma cells	mRNA	↓	[55]
	Egr1 siRNA	Mouse/Human	Astrocytes	mRNA, Protein	↓	[31]
miRNA	miR129-2	Mouse	Neurospheres	mRNA, Protein	↓	[62]

The table lists the species and type of cells or tissue in which the analyses have been performed as well as the level of detection and the observed up- (↑) or downregulation (↓) of NG2/CSPG4 expression

ISSN: 1689-1392