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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: miR-200b downregulates CFTR during hypoxia in human lung epithelial cells

Fig. 7

Model for negative regulation of CFTR expression during hypoxia by HIF-1 and miR-200b. During hypoxia, HIF-1 activity is induced and HIF-1 binds to the hypoxia response element (HRE) sequence located in CFTR 5′UTR and has been reported to decrease CFTR expression (Zheng et al. [18]). Our studies show that HIF-1 induces miR-200b expression and binds to the target sequence (TS miR-200b) located at the 3′UTR of CFTR mRNA, which further decreases CFTR mRNA and protein expression

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