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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

Fig. 3

Expression of mdr1 and p-gp in HEp-2/VCR cells after c-fos knockdown. a, b Real-time PCR analysis of the expression of c-fos and mdr1 in various groups of cells. The HEp-2/VCR cells with c-fos knockdown were named the c-fos shRNA group, the negative control (NC) was HEp-2/VCR cells transfected with an empty vector. c, d Western blot assessment of the expression of c-fos and P-gp in various groups of cells. e, f The statistical quantification analyses of c-fos and p-gp protein levels in c-fos knockdown HEp-2/VCR cells. Data are shown as the means ±SD. **p < 0.01, ***p < 0.001

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