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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

Fig. 4

MTT assayof the changes in cell sensitivity to chemotherapeutic drugs after c-fos knockdown in HEp-2/VCR cells or c-fos overexpression in HEp-2 cells. All the groups of monoclonal cells were treated with various concentrations of 5-FU for 48 h. Concentration–effect curves showing the differences in the 5-FU IC50forvarious groups of cells. a The IC50 for 5-FU in the c-fos WT group was 268.5 ± 6.51 μmol/l, which was 4.86 times that of the NC group (55.2 ± 2.31 μmol/l; p < 0.01). b The IC50 of 5-FU had decreased by 75% in the c-fos shRNA group (80.2 ± 2.3 μmol/l) compared to the value for the NC group (309.2 ± 4.21 μmol/l; p < 0.01). Data are shown as the means ±SD. **p < 0.01

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