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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance

Fig. 5

Effect of c-fos expression on the efflux function of P-gp. Cells were incubated with Rh-123 for 60 min, and then MFI (Rh-123) was determined using flow cytometric analysis. a The intracellular MFI was markedly lower in the c-fos WT group than in the NC group. b The intracellular MFI was significantly higher in the c-fos shRNA group than in the NC group. c The intracellular MFI (Rh-123) values for HEp-2/VCR cells and HEp-2 cells. Data are shown as the means ±SD. *p < 0.05

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