Skip to main content
Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Mitochonic acid 5 activates the MAPK–ERK–yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy

Fig. 5

MA-5 regulated the Bnip3-related mitophagy via the MAPK–ERK–Yap pathways. a through c Western blotting was used to analyze the changes in Yap and Bnip3. siRNA was used to silence Yap expression (si-YAP), which also reduced the expression of Bnip3. d The immunofluorescence assay of mitophagy via mitochondria and lysosome co-staining. The Yap siRNA also reduced the mitophagy. e through g SCH772984 was used to inhibit ERK activity. The ERK inhibitor also reduced Yap expression. *p < 0.05 vs. control (Ctrl) group; #p < 0.05 vs. TNFα group; †p < 0.05 vs. TNFα+MA-5 group

Back to article page

Cellular & Molecular Biology Letters

ISSN: 1689-1392

Contact us