Fig. 5
From: The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro
Norpurpureine inhibits agonist-induced elevation of [Ca2+]i in human platelets. a Typical superimposed traces of [Ca2+]i changes stimulated by 0.075 U/ml thrombin (Thr) over time, in Fura-2-AM-loaded platelets pretreated with norpurpureine at the indicated concentrations. b Concentration-dependent inhibition of norpurpureine on the maximum elevation (★ in 5A, for each curve) reached by [Ca2+]i after thrombin stimulation. Each data point is the mean ± SD (n = 3), p < 0.01(**), p < 0.001(***) vs. vehicle