Fig. 7
From: The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro
Norpurpureine prevents the agonist-induced decrease in intra-platelet cAMP levels. Platelets were pre-treated for 10 min with vehicle (0.25% DMSO), 220 μM norpurpureine and 10 μM IBMX; and stimulated with 1 μg/ml collagen (in platelet-rich plasma, PRP) and 0.075 U/ml thrombin (in washed platelets, WP). Data are the means ± SD (n = 2, done in triplicate). p < 0.05 (*) compare to basal (PRP or WP) and p < 0.05 (†) compared to collagen- or thrombin-activated platelets