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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway

Fig. 6

Mst1 regulated mitochondrial fission via the JNK-Drp1 pathway. ad Western blotting was performed to analyze the signaling pathways. SP600125 (SP) was used to inhibit JNK activation (WT + SP). Anisomycin (Ani), an activator of JNK, was applied in Mst1-knockout cells to reactivate the JNK (Mst1KO + Ani). e and f Mitochondrial fission and mitochondrial length were measured with JNK activation and inhibition. *p < 0.05 vs. ctrl group, #p < 0.05 vs. WT-cell+hypoxia, p < 0.05 vs. Mst1KO-cell+hypoxia

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