Fig. 4

miR-96 and miR-26a downregulate SLEP and PDGFRA. a and b The sequence sites of miR-96 and miR-26a and the binding UTR of SLEP and PDGFRA. c miR-96 and miR-26a inhibit the expression of SLEP and PDGFRA at the translational level in HUVECs in vitro. The protein bonds are reduced in both groups. d and e The luciferase activity assay with the SLEP and PDGFRA UTRs. MiR-96 and miR-26a reduced the expression of SLEP and PDGFRA by targeting their UTRs. However, these miRNAs did not affect the activity of luciferase gene-containing mutant UTR. *p < 0.05, **p < 0.01). WT: wild-type (WT-UTR contains the binding site of miR-96 or miR-26a), MUT: mutant (MUT-UTR deletes the binding site of miR-96 or miR-26a)