Fig. 1

A simplified diagram of the interaction between the protein components of the nuclear lamina and the nuclear envelope with chromatin and the cytoskeleton. Only well documented proteins with high importance for biological functions are demonstrated. Please note that we included two fly-specific proteins (YA and otefin) along with the typical vertebrate proteins. ONM – outer nuclear membrane; INM – inner nuclear membrane; NL – nuclear lamina; NET – nuclear envelope transmembrane proteins; LBR – lamin B receptor; NPC – nuclear pore complex