Fig. 1From: The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cellsNotch signaling up-regulates Asb2 transcription and NF-κB activation. CCRF-CEM cells and MOLT-4 cells were treated with DMSO (vehicle) or with 10 μM GSI for 24 h. Untreated cells served as the control. a Levels of Asb2 mRNA as assessed by qRT-PCR. b Levels of NF-κB-p65 in the nuclei of CCRF-CEM cells and MOLT-4 cells. The data are presented as the means ± SD, **P < 0.01 versus DMSO control. Each assay was conducted in triplicateBack to article page