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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells

Fig. 5

Asb2 expression enhances viability and inhibits apoptosis of T-ALL cells. CCRF-CEM cells were transduced with lentivirus carrying empty vector, Asb2, control shRNA or Asb2-shRNA2. a Cell viability was analyzed by MTT assay. Each bar represents the mean ± SD of three independent experiments. **p < 0.01 versus empty vector-transduced cells; ǂ ǂp < 0.01 versus control shRNA-transduced cells. Control group refers to non-transduced cells. b Annexin V-FITC/PI staining of the indicated cells. Each bar represents the mean ± SD of three independent experiments. **p < 0.01 versus vehicle vector-transduced cells; ǂ ǂp < 0.01 versus control shRNA-transduced cells. c MOLT-4 cells were transduced with lentivirus carrying empty vector, Asb2, control shRNA or Asb2-shRNA2. The effects of Asb2 on apoptosis associative protein (caspase 3) in MOLT-4 were determined by Western blot with GAPDH as a loading control

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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