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Table 1 Hemodynamic and biochemical parameters

From: Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice

Parameter Control LPS
   DMSO Diacerein
Body weight (g) 21.4 ± 0.8 18.7 ± 1.0** 19.2 ± 0.9** 19.4 ± 0.4**
MAP, (mmg) 118.3 ± 12.4 102.4 ± 14.0 109.6 ± 11.8 114.1 ± 9.5
Water intake (ml/100 g/12 h) 5.8 ± 0.6 3.0 ± 0.4** 2.7 ± 0.5** 4.7 ± 0.3##
Urine volume (ml/100 g/12 h) 2.8 ± 0.5 1.0 ± 0.1** 1.2 ± 0.2** 2.2 ± 0.2##
Creatinine (mM) 22.1 ± 2.5 72.3 ± 2.8** 73.3 ± 5.1** 34.0 ± 2.1##
Creatinine clearance (mL/min/kg) 5.8 ± 0.3 3.9 ± 0.5** 4.2 ± 0.4** 5.3 ± 0.4##
BUN (mM) 5.6 ± 0.9 14.4 ± 1.1** 15.8 ± 1.5** 6.7 ± 0.8##
FENa (%) 0.6 ± 0.1 1.8 ± 0.3** 1.2 ± 0.1** 0.9 ± 0.2##
Urine osmolarity (mOsm/L) 3166 ± 192 1520 ± 84** 1487 ± 95** 2674 ± 114##
Serum osmolarity (mOsm/L) 314 ± 5 342 ± 3** 340 ± 6** 319 ± 2##
  1. Variables were measured at the end of 72-h experimental period. Values are expressed as means±SEM, MAP mean arterial pressure, BUN blood urea nitrogen, FENa fractional excretion of sodium; **P < 0.01 vs. control; ##P < 0.01 vs. LPS, n = 10 in each group