Table 1 Hemodynamic and biochemical parameters
Parameter | Control | LPS | ||
|---|---|---|---|---|
– | DMSO | Diacerein | ||
Body weight (g) | 21.4 ± 0.8 | 18.7 ± 1.0** | 19.2 ± 0.9** | 19.4 ± 0.4** |
MAP, (mmg) | 118.3 ± 12.4 | 102.4 ± 14.0 | 109.6 ± 11.8 | 114.1 ± 9.5 |
Water intake (ml/100 g/12 h) | 5.8 ± 0.6 | 3.0 ± 0.4** | 2.7 ± 0.5** | 4.7 ± 0.3## |
Urine volume (ml/100 g/12 h) | 2.8 ± 0.5 | 1.0 ± 0.1** | 1.2 ± 0.2** | 2.2 ± 0.2## |
Creatinine (mM) | 22.1 ± 2.5 | 72.3 ± 2.8** | 73.3 ± 5.1** | 34.0 ± 2.1## |
Creatinine clearance (mL/min/kg) | 5.8 ± 0.3 | 3.9 ± 0.5** | 4.2 ± 0.4** | 5.3 ± 0.4## |
BUN (mM) | 5.6 ± 0.9 | 14.4 ± 1.1** | 15.8 ± 1.5** | 6.7 ± 0.8## |
FENa (%) | 0.6 ± 0.1 | 1.8 ± 0.3** | 1.2 ± 0.1** | 0.9 ± 0.2## |
Urine osmolarity (mOsm/L) | 3166 ± 192 | 1520 ± 84** | 1487 ± 95** | 2674 ± 114## |
Serum osmolarity (mOsm/L) | 314 ± 5 | 342 ± 3** | 340 ± 6** | 319 ± 2## |