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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Angiogenesis after administration of basic fibroblast growth factor induces proliferation and differentiation of mesenchymal stem cells in elastic perichondrium in an in vivo model: mini review of three sequential republication-abridged reports

Fig. 5

Evaluation of the effect of bFGF administration on cartilage proliferation. a. Concentration-dependent effect of bFGF on auricular chondrogenesis. The box plot shows the cartilage neogenesis rate for different concentrations of bFGF. Kruskal-Wallis analysis revealed a highly significant difference among the groups (P < 0.0001). Post hoc comparisons by the Fisher test indicated significant differences between the groups injected with more than 5 μg/ml and the control group, but the difference between animals injected with 1 μg/ml bFGF and the control group was not statistically significant. b. Blocking of bFGF stimulation using an anti-bFGF neutralizing antibody. The box plot shows the cartilage neogenesis rate immediately after injection of bFGF, immediately after and 1 week after injection of bFGF, immediately after and 2 weeks after injection of bFGF, 1 week after injection of bFGF, 2 weeks after injection of bFGF, and the control. Kruskal Wallis analysis revealed a significant difference between the three groups immediately after injection of bFGF and the control group (P < 0.01), but suppression of chondrogenesis at 1 week and 2 weeks after bFGF injection was not recognized in comparison with the control group. **P < 0.01. “Reprinted with permission from (Koizumi, N. (2010). Basic fibroblast growth factor stimulates proliferation and differentiation of perichondrocytes of rabbit auricular cartilage in vivo. Journal of Kanazawa Medical University, 35, 122–130.). Copyright (2010) publication administration of Kanazawa Medical University”

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