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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Elevated IL-33 promotes expression of MMP2 and MMP9 via activating STAT3 in alveolar macrophages during LPS-induced acute lung injury

Fig. 1

Establishment of LPS-induced ALI rat model. (a-d) LPS-induced lung injury in experimental rats, as characterized by lung wet/dry ratio (A), protein contents in BALF (b), total cells in BALF (c) and macrophages in BALF (d). (e-i) Levels of IL-33 (e), TNF-α (f), MMP2 (g), MMP9 (h), and TIMP1 (i) in BALF of LPS-induced ALI rats. (j) mRNA level of IL-33 in F4/80+ AMs purified from BALF of LPS-induced ALI rats. (k) Protein levels of ST-2 and IL-1RAP in F4/80+ AMs purified from BALF of LPS-induced ALI rats. (l) Protein levels of p-STAT3 and STAT3 in F4/80+ AMs purified from BALF of LPS-induced ALI rats. Data are shown as means±SD (N = 9 per group). Two-tailed t test was used in the statistical analyses. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. control

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