Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells

Table 2 Cytotoxicity of drugs in A549/MDR cell after siNOLC1 transfection

Drug	NC-IC50 (μg/ml)	siNOLC1-IC50 (μg/ml)	RI
5-fluorouracil	130.53	75.71	0.58
Paclitaxel	83.52	17.54	0.21
Mitomycin	8.64	3.89	0.45
Vinorelbine Tartrate	12.40	18.47	1.49
Cisplatin	33.00	10.89	0.33
Gemcitabine Hydrochloride	19.05	7.05	0.37

IC50 50% inhibitory concentration, RI resistance index, DDP Cisplatin, MDR multidrug resistance

ISSN: 1689-1392