Fig. 1
From: The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice
The antitumor effect of siPD-1 and siCTLA-4 in the H22 allograft. CT = control, siPD-1 = group injected with siRNA for PD-1, siCTLA-4 = group injected with siRNA for CTLA-4, siPD-1 + siCTLA-4 = group injected with siRNA for PD-1 + CTLA-4. a –Photo of four representative tumor-bearing mice (one per group). The picture was taken 30 days after inoculation with H22 cells. b – Photo of 5 solid tumors from each group. Tumors were removed from mice 30 days after inoculation with H22 cells. c – Change curve of tumor volume. Tumor diameter was measured with a caliper once every 4 days for 30 days and volume was calculated as described in section observing the physiological condition of the H22 mice 2.4. d – Survival rate of mice. These results indicate that siRNAs markedly inhibited the growth of tumor