Fig. 3
From: The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice
PCR results for PD-1, PD-L1, CTLA-4, IFN-γ, IL-6 and Survivin mRNA in various tissues. CT = control, siPD-1 = group injected with siRNA for PD-1, siCTLA-4 = group injected with siRNA for CTLA-4, siPD-1 + siCTLA-4 = group injected with siRNA for PD-1 + CTLA-4. a – Level of IFN-γ mRNA in the tumors. b – Level of Survivin mRNA in the tumors. c – Level of PD-L1 mRNA in the tumors. d – Level of IL-6 mRNA in the tumors. e – Level of PD-1 mRNA in the spleen. f – Level of CTLA-4 mRNA in the spleen. g – Level of IFN-γ mRNA in the spleen. h – Level of IFN-γ mRNA in the liver. i – Level of PD-L1 mRNA in the liver. The mRNA expressions of some genes in the siRNA groups were significantly different than those in the control group (*p < 0.05, **p < 0.01)