Fig. 4
From: The suppressive effect of co-inhibiting PD-1 and CTLA-4 expression on H22 hepatomas in mice
Bax and Bcl-2 assays. The levels of Bax and Bcl-2 were determined using western blot. a – Photo of the western blot gels for the four tumor samples. CT = control, siPD-1 = group injected with siRNA for PD-1, siCTLA-4 = group injected with siRNA for CTLA-4, siPD-1 + siCTLA-4 = group injected with siRNA for PD-1 + CTLA-4. b – Quantitative analysis of Bax and Bcl-2 expressions. Compared with the control group, the Bax-to-Bcl-2 ratio significantly increased in all siRNA groups (**p < 0.01, *p < 0.05)