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Fig. 8 | Cellular & Molecular Biology Letters

Fig. 8

From: Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway

Fig. 8

The effects of tetramethylpyrazine (TMP) on the PI3K/Akt/GSK-3β pathway. The phosphorylation of PI3K, Akt and GSK-3 were detected using a western blotting assay. The expression of Bax-2, Bcl-2, PI3K, Akt, GSK-3β, MDA5 and SOD1 were detected using a western blotting assay. Values are expressed as means ± SD. #p < 0.05, ##p < 0.01 compared to control group. *p < 0.05, **p < 0.01compared to ISO group. Control: rats pretreated with saline solution. ISO: rats pretreated with saline solution and treated with isoproterenol (ISO). ISO + Pro and Pro: rats pretreated with propranolol (Pro) and treated with ISO. ISO + TMP: rats pretreated with indicated dosage of TMP and treated with ISO

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