Fig. 4

Honokiol ameliorates AKI in septic mice by targeting HO-1. Renal pathology PAS staining (× 200) was performed in CLP-induced septic mice for 24 h (a). The mRNA (b) and protein (c) expression levels of HO-1 were measured by RT-qPCR and western blotting, respectively, in the kidney of septic mice. The mRNA expression levels of Bcl-2 and BAX were measured by RT-qPCR in the kidney of septic mice (d). Values are expressed as mean ± SEM, n = 10 in Con or H + CLP group and n = 8 in CLP or L + CLP group. ^*** P < 0.001, versus control group; ^# P < 0.05, ^## P < 0.01, ^### P < 0.001, versus CLP single treatment group