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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway

Fig. 7

Honokiol blocks LPS-induced cell growth inhibition and apoptosis by targeting miR-218-5p/HO-1. The expression levels of miR-218-5p were measured using RT-qPCR assays in the kidney from septic mice with or without honokiol treatment (a) and in LPS-stimulated GMCs with or without honokiol treatment (b). GMCs were exposed to different conditions, cell viability was measured by CCK-8 assay (c); cell apoptosis was performed by flow cytometry (d and e); the mRNA (f) and protein (g) expression levels of HO-1 were measured by RT-qPCR and western blotting, respectively. Values are expressed as mean ± SEM, n = 3 in each group. * P < 0.05 versus control group; # P < 0.05 versus LPS treated group; & P < 0.05 versus honokiol+ LPS treated group

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