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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: MiR-107 function as a tumor suppressor gene in colorectal cancer by targeting transferrin receptor 1

Fig. 4

TFR1 overexpression restored the miR-107-mediated inhibitory effect on SW620 cells. a TFR1 overexpression attenuated miR-107-induced suppressive effect on SW620 cells. SW620 cells were treated with NC mimic or miR-107 mimics for 24 h, and then the cell viabilities were determined with the MTT assay. b and c TFR1 overexpression restores the miR-107-mediated effect on the horizontal migration of SW620 cells. SW620 cells were transfected with NC vector or TFR1 vector, and then used for the wound-healing assay. Representative images (100× magnification) and quantitative data are shown in (b and c), respectively. d and e TFR1 overexpression attenuates the miR-107-mediated suppressive effect on the vertical migration and invasion of SW620 cells. The SW620 cells were transfected with NC vector or TFR1 vector, and then subjected to transwell migration and transwell invasion assays. Representative images (100 × magnification) and quantitative data are shown in (d and e), representatively. Quantitative data are presented as the means ± SEM. *** p < 0.01 and *** p < 0.001 compared with NC vector group, #p < 0.05 compared with NC vector+miR-107 mimic group

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