Table 1 Substrates of SIRT1 action and corresponding biological function

PGC-1α

Antioxidant stress, Regulate mitochondrial function and Regulating the metabolism of glucose and lipid

NF-ƙB

Inhibition of inflammation, Regulation of apoptosis

FOXO, p53

Control of cell cycle, Antioxidant stress and Regulation of apoptosis

NRF2

Antioxidant stress, Inhibition of inflammation