Table 2 The main role of each SIRT1 agonist/inhibitor in toxic damage caused by toxicants

Res

Antioxidant stress, Inhibits apoptosis, anti-inflammatory, protect endothelial cells, potentiated NAD⁺ loss

Melatonin

improve the functional status of mitochondria

SRT1720

Protect endothelial cells

SRT2104

Anti-inflammatory, inhibits activation of coagulation

Rosuvastatin

Anti-inflammatory

SaLB

Antioxidant stress

NAM

Prevents NAD⁺ Depletion

Sirtinol

Prevents NAD⁺ Depletion