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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosis

Fig. 4

GASL1 downregulated TGF-β1 to inhibit AC16 cell apoptosis. Expression data analysis showed that expression levels of TGF-β1 and GASL1 were significantly increased in AC16 cells compared to two controls (Control, C; Negative control, NC) at 24 h after transfections (a). In addition, TGF-β1 overexpression failed to affect GASL1 in AC16 cells (b), while GASL1 overexpression mediated the downregulation of TGF-β1 at both mRNA and protein levels (c). Cell apoptotic data analyzed by one-way ANOVA and Tukey test showed that overexpression of GASL1 led to decreased, while TGF-β1 overexpression led to increased apoptotic rate of cardiomyocytes under H2O2 treatment. In addition, TGF-β1 overexpression attenuated the effect of GASL1 overexpression (d) (*, p < 0.05)

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