Fig. 1

MiR-216a-5p was significantly down-regulated in ESCC tissues and cell lines. a MiR-216a-5p expression levels in 25 pairs of ESCC tissues compared with matched adjacent normal tissues were determined using qRT-PCR. b MiR-216a-5p expression in four ESCC cell lines and normal esophageal epithelial HET-1A cells was measured using qRT-PCR. *p < 0.05, **p < 0.01, ***p < 0.001 vs. normal group; ESCC, esophageal squamous cell carcinoma; qRT-PCR, quantitative real-time PCR