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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancer

Fig. 1

Malat1 is remarkably overexpressed in CRC, and associates with autophagy activation in CRC. A-B: qRT-PCR assay shows Malat1 expression in CRC tissues and adjacent normal tissues (a), 4 CRC cell lines and a human normal colorectal mucosa cell line FHC (b). HCT116 cell line and SW620 cell line were chosen to perform subsequent experiments. c-d Western blot shows that LC3-II/I and p62/SQSTM1 expression in CRC tissues and adjacent normal tissues (a), CRC cell lines and human normal colorectal mucosa cell line (d), the columns show the mean for three separate experiments. e qRT-PCR assay shows LC3-II/I expression in CRC tissues and adjacent normal tissues. f A significant positive correlation between Malat1 and LC3-II mRNA levels in CRC tissues. Bars, sd. *p < 0.05, **p < 0.01

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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