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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancer

Fig. 4

miR-101 works as a target RNA of Malat1. a-b Dual-luciferase reporter assay shows that co-transfection with miR-101 overexpression mimics significantly reduces luciferase activity of the reporter containing Malat1-WT, but it has less effect on the reporter containing Malat1-MUT in HCT116 and SW620 cells. c qRT-PCR assay shows miR-101 expression in CRC tissues and adjacent normal tissues. d An inverse correlation between Malat1 and miR-101 expression in CRC tissues. e qRT-PCR assay shows the effects of Malat1 down-regulation or up-regulation on miR-101 expression in HCT116 and SW620 cells. The columns show the mean for three separate experiments. Bars, sd. *p < 0.05, **p < 0.01

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