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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Costunolide reduces glycolysis-associated activation of hepatic stellate cells via inhibition of hexokinase-2

Fig. 3

Blockade of aerobic glycolysis contributes to the reduction in HSC activation by costunolide. Primary rat HSCs at passages 3 through 5 were treated with costunolide and/or 2-DG at the indicated concentrations for 24 h. a – Real-time PCR for determining the mRNA expression of α-SMA and collagen I. b – Western blot assay for determining the protein expression of α-SMA and collagen I with quantification of the blots. Statistics: **p < 0.01 vs. control

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