Fig. 2

Pharmacological inhibition of MAO-A activity reduces the frequency of tumorsphere-forming cells in human breast tumor cell lines. a IC₅₀ curves from sphere-forming assays with 3 selective MAO-A inhibitors in the MCF-7 and HCC1954 human breast tumor cell lines. b IC₅₀ curves for tetrindole using sphere forming assays with a panel of 6 human breast tumor cell lines. Data points represent the number of tumorspheres formed at each concentration, relative to the vehicle treated cells. IC₅₀ curves were generated using GraphPad Prism 7.0. Error bars represent standard error from three technical replicates. A value of 0.01 nM was used in IC₅₀ calculations as the vehicle-treated control