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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1

Fig. 2

MicroRNA-146a deficiency increased MIRI, a, b. MicroRNA-146a deficiency reduced cardiac function. Echocardiography was used to examine the heart function of WT and KO mice after MIR at the first and third days, EF and FS were detected. Compared with WT, *P < 0.05, n = 6. c MicroRNA-146a deficiency increased the myocardial infarct size. WT and KO mice were subjected to I/R, and then AAR and infarct size were subsequently measured using Evans Blue/TTC staining (10× magnification). WT, wild type; KO, microRNA-146a−/−; IR, ischaemia reperfusion; EF, ejection fraction; FS, fractional shortening; TTC, triphenyltetrazolium chloride; AAR, area at risk; IS, infarction size. Compared with WT, *P < 0.05, n = 6

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