Fig. 4
From: MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1
Med1 was one of the target genes of microRNA-146a. a WT and KO mice were subjected to MIR, and then possible target genes were checked with microarray. The heatmap showed 19 apoptosis related genes were up-regulated. b WT and KO mice were stimulated with MIR, and the mRNA levels of IL2rb, Dapk3, Lspl, Aldh2, and Med1 were detected through qRT-PCR, with 18 s RNA as an internal reference. Compared with 18 s RNA, *P < 0.05, n = 6. c 293 T cells were transfected with PGL3 luciferase reporter plasmids containing wild-type or mutated Med1 3′UTR and microRNA-146a, using NC as controls. NC, negative control. Compared with other groups, *P < 0.05, n = 6