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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling

Fig. 1

The effect of continuous hypoxia for 1, 3, 5 and 7 days on MSC proliferation and gene expression of osteogenic markers. a MSC proliferation on days 1, 3, 5 and 7 of culture including 1, 3, 5 or 7 days of hypoxia. b-h Osteogenic and Vegf gene expression on day 7. Data are the means ± SD from 5 independent experiments, n = 5. Significant effect of the treatment: *p < 0.05, **p < 0.01 and ***p < 0.001. H1, H3, H5 and H7 represent hypoxia for 1, 3, 5 and 7, respectively, whule 0D, 1D, 3D, 5D and 7D represent 0, 1, 3, 5 or 7 total days of culture, respectively. Col1α1: collagen I alpha1, Runx2: Runt-related transcription factor 2, Alp: alkaline phosphatase, Osx: osterix, Ocn: osteocalcin and Vegf: vascular endothelial growth factor

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