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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling

Fig. 5

Histology of bone defects from mouse femurs and associated Hif-1α and Alp gene expressions. a Representative images of mouse femoral bone defect histological section (H & E staining). b and cHif-1α and Alp gene expression in mouse femoral bone defects on day 7. Data of quantitative analysis are the means ± SD, n = 5. Significant effect of the treatment compared to the blank group: *p < 0.05 and ***p < 0.001; the control group: #p < 0.05, ###p < 0.001; the CoCl2 group: &&&p < 0.001; and the CoCl2 + inhibitor group: $$$p < 0.001. Inhibitor: STAT3 inhibitor, OB: original bone, NB: newly formed bone, Red arrow: defect area with failure to regenerate bone

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