Fig. 7
Representative immunohistochemistry images for proteins in bone defect tissue sections. a – HIF-1α. b – p-STAT3. c – ALP. d – Quantitative analysis of HIF-1α, p-STAT3 and ALP protein expression in bone defect area. Significant effect of the treatment compared to the control group: *p < 0.05 and ***p < 0.001; the CoCl2 group: #p < 0.05 and ###p < 0.001; and the CoCl2 + inhibitor group: &p < 0.05 and &&p < 0.01. Inhibitor: STAT3 inhibitor