Fig. 4
The ERE was identified functionally within the SREBP2 promoter. a Schematic diagram of luciferase reporter constructs. Blank control: pGL3-basic plasmid; SREBP2-Luc: pGL3-basic plasmid with the putative ERE-like sequence insert; SREBP2-Mut: pGL3-basic plasmid with the mutative ERE-like sequence insert. b Luciferase activities of three report systems in the presence or absence of E2 (10− 7 mol/l) were compared with each other. The experiments were repeated three times and data are presented as means ± SEM. **p < 0.01 compared with the value in the non-E2-treated control group. SREBP2: sterol regulatory element-binding protein 2; E2: estradiol