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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway

Fig. 5

Circ-CAMK2A promotes LUAD cell migration and invasion by elevating fibronectin 1 via reducing miR-615-5p. a, b mRNA (a) and protein (b) expression levels of fibronectin 1, MMP2, and MMP9 were respectively measured by qRT-PCR and western blotting in circ-CAMK2A-overexpressing A549 cells co-transfected with miR-615-5p mimics. c, d mRNA (c) and protein (d) expression levels of fibronectin 1, MMP2, and MMP9 were respectively measured by qRT-PCR and western blotting in circ-CAMK2A-knockdown HCC827 cells co-transfected with miR-615-5p inhibitors. e Representative IHC staining for fibronectin 1 protein expression in LUAD tissues. f Correlation between circ-CAMK2A and fibronectin 1 expression in LUAD tissues. g Migratory and invasive capabilities were respectively detected by wound healing and transwell assays in circ-CAMK2A-overexpressing A549 cells co-transfected with miR-615-5p mimics or si-fibronectin 1. h Migratory and invasive capabilities were respectively detected by wound healing and transwell assays in circ-CAMK2A-knockdown HCC827 cells co-transfected with miR-615-5p inhibitors or fibronectin 1 expression plasmid. g Schematic diagram of circ-CAMK2A/miR-615-5p/fibronectin 1 regulatory pathway in LUAD metastasis

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