Fig. 7

GNAS expression contributes to HCC development in mice and is related to poor survival. a GNAS knockout significantly inhibits tumor growth in vivo. Representative images of xenograft tumors from the nude mice. b IHC analysis of GNAS and p-STAT3 in tumor tissues (× 200 magnification). mRNA (c) and protein (d) expression analysis of GNAS in clinical tumor and para-tumor normal tissue samples. e GNAS mRNA expression analysis using TCGA database (p < 1E-12). f Survival analysis of high or low expression of GNAS on liver hepatocellular carcinoma patient from TCGA database (p = 0.028)