Adipose-derived stromal cells in regulation of hematopoiesis

Table 1 Comparison between ASCs and BM-MSCs

		ASCs	BM-MSCs	Reference
Source		Adipose tissue	Bone marrow	[20]
Surface markers	CD13 CD14 CD19 CD29 CD44 CD45 CD49d CD90 CD105 CD106 CD166 HLA-DR	+ - - + + - + + + - + -	+ - - + + - - + + + + -	[12, 14, 15, 21, 22]
Cytokines, chemokines, and specific proteins	SCF G-CSF GM-CSF M-CSF SDF-1 IL-1α IL-6 IL-8 IL-12 TNF-α Leptin Adipsin	+ + + + + - + + - + + +	+ + + + + + + + + + - -	[18, 19, 23]
Differentiation	Adipogenesis Chondrogenesis Osteogenesis Myogenesis Angiopoiesis Neurogenesis	+ + + + + +	+ + + + + +	[16, 17, 20]
Cell yield		0.5 × 10⁴ - 2 × 10⁵ cells per gram	1 × 10³ cells per mL	[12, 15]
Clinical trials		185	217
Approved products		Alofisel	Prochymal, Stempeusel, TEMCELL, Hearticellgram-AMI	[24, 25]

The number of registered clinical trials is obtained from the website of the U.S. National Library of Medicine under the terms “adipose-derived stromal/stem cells” and “bone marrow mesenchymal stromal/stem cells” respectively (until September 2019)

ISSN: 1689-1392