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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: RETRACTED ARTICLE: Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3

Fig. 2

Hypoxia induced cardiomyocyte damage and altered the expressions of miR-483-5p and MAPK3. a AC16 cells were maintained in a hypoxic incubator (94% N2, 5% CO2 and 1% O2) for 12, 24 and 48 h, followed by a CCK-8 assay, which showed decreasing cell viability. b through e After 24 h hypoxia treatment, AC16 cells underwent apoptosis analysis using flow cytometry and oxidative damage analysis for the content of MDA, and the activities of SOD and CAT using commercial assay kits. f The expression levels of miR-483-5p and MAPK3 were determined via quantitative real-time PCR in AC16 cells after 24 h under hypoxic conditions. Data are indicated as means ± SD of three independent experiments. **p < 0.01, ***p < 0.001, as compared with normoxia

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