TY - JOUR AU - Vinay, D. S. AU - Cha, K. AU - Kwon, B. S. PY - 2006 DA - 2006// TI - Dual immunoregulatory pathways of 4-1BB signaling JO - J Mol Med (Berl) VL - 84 UR - https://doi.org/10.1007/s00109-006-0072-2 DO - 10.1007/s00109-006-0072-2 ID - Vinay2006 ER - TY - JOUR AU - Kwon, B. S. AU - Weissman, S. M. PY - 1989 DA - 1989// TI - cDNA sequences of two inducible T-cell genes JO - Proc Natl Acad Sci U S A VL - 86 UR - https://doi.org/10.1073/pnas.86.6.1963 DO - 10.1073/pnas.86.6.1963 ID - Kwon1989 ER - TY - JOUR AU - Weiss, A. AU - Littman, D. R. PY - 1994 DA - 1994// TI - Signal transduction by lymphocyte antigen receptors JO - Cell. VL - 76 UR - https://doi.org/10.1016/0092-8674(94)90334-4 DO - 10.1016/0092-8674(94)90334-4 ID - Weiss1994 ER - TY - JOUR AU - Vinay, D. S. AU - Kwon, B. S. PY - 1998 DA - 1998// TI - Role of 4-1BB in immune responses JO - Semin Immunol VL - 10 UR - https://doi.org/10.1006/smim.1998.0157 DO - 10.1006/smim.1998.0157 ID - Vinay1998 ER - TY - JOUR AU - Kim, J. O. AU - Kim, H. W. AU - Baek, K. M. AU - Kang, C. Y. PY - 2003 DA - 2003// TI - NF-κB and AP-1 regulate activation-dependent CD137 (4-1BB) expression in T cells JO - FEBS Lett VL - 541 UR - https://doi.org/10.1016/S0014-5793(03)00326-0 DO - 10.1016/S0014-5793(03)00326-0 ID - Kim2003 ER - TY - JOUR AU - Croft, M. PY - 2003 DA - 2003// TI - Co-stimulatory members of the TNFR family: keys to effective T-cell immunity JO - Nat Rev Immunol VL - 3 UR - https://doi.org/10.1038/nri1148 DO - 10.1038/nri1148 ID - Croft2003 ER - TY - JOUR AU - Watts, T. H. PY - 2005 DA - 2005// TI - TNF/TNFR family members in costimulation of T cell responses JO - Annu Rev Immunol VL - 23 UR - https://doi.org/10.1146/annurev.immunol.23.021704.115839 DO - 10.1146/annurev.immunol.23.021704.115839 ID - Watts2005 ER - TY - JOUR AU - Vinay, D. S. AU - Kwon, B. S. PY - 2011 DA - 2011// TI - 4-1BB signaling beyond T cells JO - Cell Mol Immunol VL - 8 UR - https://doi.org/10.1038/cmi.2010.82 DO - 10.1038/cmi.2010.82 ID - Vinay2011 ER - TY - JOUR AU - Barsoum, A. L. AU - Schwarzenberger, P. O. PY - 2014 DA - 2014// TI - Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer JO - Cell Mol Biol Lett VL - 19 UR - https://doi.org/10.2478/s11658-014-0203-7 DO - 10.2478/s11658-014-0203-7 ID - Barsoum2014 ER - TY - JOUR AU - Drenkard, D. AU - Becke, F. M. AU - Langstein, J. AU - Spruss, T. AU - Kunz-Schughart, L. A. AU - Tan, T. E. PY - 2007 DA - 2007// TI - CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity JO - FASEB J VL - 21 UR - https://doi.org/10.1096/fj.05-4739com DO - 10.1096/fj.05-4739com ID - Drenkard2007 ER - TY - JOUR AU - Mittler, R. S. AU - Foell, J. AU - McCausland, M. AU - Strahotin, S. AU - Niu, L. AU - Bapat, A. PY - 2004 DA - 2004// TI - Anti-CD137 antibodies in the treatment of autoimmune disease and cancer JO - Immunol Res VL - 29 UR - https://doi.org/10.1385/IR:29:1-3:197 DO - 10.1385/IR:29:1-3:197 ID - Mittler2004 ER - TY - JOUR AU - Mittler, R. S. AU - Bailey, T. S. AU - Klussman, K. AU - Trailsmith, M. D. AU - Hoffmann, M. K. PY - 1999 DA - 1999// TI - Anti–4-1BB monoclonal antibodies abrogate T cell–dependent humoral immune responses in vivo through the induction of helper T cell anergy JO - J Exp Med VL - 190 UR - https://doi.org/10.1084/jem.190.10.1535 DO - 10.1084/jem.190.10.1535 ID - Mittler1999 ER - TY - JOUR AU - Miller, R. E. AU - Jones, J. AU - Le, T. AU - Whitmore, J. AU - Boiani, N. AU - Gliniak, B. PY - 2002 DA - 2002// TI - 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner JO - J Immunol VL - 169 UR - https://doi.org/10.4049/jimmunol.169.4.1792 DO - 10.4049/jimmunol.169.4.1792 ID - Miller2002 ER - TY - JOUR AU - Saoulli, K. AU - Lee, S. Y. AU - Cannons, J. L. AU - Yeh, W. C. AU - Santana, A. AU - Goldstein, M. D. PY - 1998 DA - 1998// TI - CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand JO - J Exp Med VL - 187 UR - https://doi.org/10.1084/jem.187.11.1849 DO - 10.1084/jem.187.11.1849 ID - Saoulli1998 ER - TY - JOUR AU - Cannons, J. L. AU - Hoeflich, K. P. AU - Woodgett, J. R. AU - Watts, T. H. PY - 1999 DA - 1999// TI - Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB JO - J Immunol VL - 163 ID - Cannons1999 ER - TY - JOUR AU - Galoczova, M. AU - Coates, P. AU - Vojtesek, B. PY - 2018 DA - 2018// TI - STAT3, stem cells, cancer stem cells and p63 JO - Cell Mol Biol Lett VL - 23 UR - https://doi.org/10.1186/s11658-018-0078-0 DO - 10.1186/s11658-018-0078-0 ID - Galoczova2018 ER - TY - JOUR AU - Pilon-Thomas, S. AU - Kuhn, L. AU - Ellwanger, S. AU - Janssen, W. AU - Royster, E. AU - Marzban, S. PY - 2012 DA - 2012// TI - Brief communication: efficacy of adoptive cell transfer of tumor infiltrating lymphocytes after lymphopenia induction for metastatic melanoma JO - J Immunother VL - 35 UR - https://doi.org/10.1097/CJI.0b013e31826e8f5f DO - 10.1097/CJI.0b013e31826e8f5f ID - Pilon-Thomas2012 ER - TY - JOUR AU - Restifo, N. P. AU - Dudley, M. E. AU - Rosenberg, S. A. PY - 2012 DA - 2012// TI - Adoptive immunotherapy for cancer: harnessing the T cell response JO - Nat Rev Immunol VL - 12 UR - https://doi.org/10.1038/nri3191 DO - 10.1038/nri3191 ID - Restifo2012 ER - TY - JOUR AU - Rosenberg, S. A. AU - Restifo, N. P. PY - 2015 DA - 2015// TI - Adoptive cell transfer as personalized immunotherapy for human cancer JO - Science. VL - 348 UR - https://doi.org/10.1126/science.aaa4967 DO - 10.1126/science.aaa4967 ID - Rosenberg2015 ER - TY - JOUR AU - Radvanyi, L. G. AU - Bernatchez, C. AU - Zhang, M. AU - Fox, P. S. AU - Miller, P. AU - Chacon, J. PY - 2012 DA - 2012// TI - Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients JO - Clin Cancer Res VL - 18 UR - https://doi.org/10.1158/1078-0432.CCR-12-1177 DO - 10.1158/1078-0432.CCR-12-1177 ID - Radvanyi2012 ER - TY - JOUR AU - Paulos, C. M. AU - Wrzesinski, C. AU - Kaiser, A. AU - Hinrichs, C. S. AU - Chieppa, M. AU - Cassard, L. PY - 2007 DA - 2007// TI - Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling JO - J Clin Invest VL - 117 UR - https://doi.org/10.1172/JCI32205 DO - 10.1172/JCI32205 ID - Paulos2007 ER - TY - JOUR AU - Chacon, J. A. AU - Wu, R. C. AU - Sukhumalchandra, P. AU - Molldrem, J. J. AU - Sarnaik, A. AU - Pilon-Thomas, S. PY - 2013 DA - 2013// TI - Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8+ melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0060031 DO - 10.1371/journal.pone.0060031 ID - Chacon2013 ER - TY - JOUR AU - Hernandez-Chacon, J. A. AU - Li, Y. AU - Wu, R. C. AU - Bernatchez, C. AU - Wang, Y. AU - Weber, J. PY - 2011 DA - 2011// TI - Co-stimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances anti-tumor effector function JO - J Immunother VL - 34 UR - https://doi.org/10.1097/CJI.0b013e318209e7ec DO - 10.1097/CJI.0b013e318209e7ec ID - Hernandez-Chacon2011 ER - TY - JOUR AU - Ye, Q. AU - Song, D. G. AU - Poussin, M. AU - Yamamoto, T. AU - Best, A. AU - Li, C. PY - 2014 DA - 2014// TI - CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor JO - Clin Cancer Res VL - 20 UR - https://doi.org/10.1158/1078-0432.CCR-13-0945 DO - 10.1158/1078-0432.CCR-13-0945 ID - Ye2014 ER - TY - JOUR AU - Weigelin, B. AU - Bolaños, E. AU - Teijeira, A. AU - Martinez-Forero, I. AU - Labiano, S. AU - Azpilikueta, A. PY - 2015 DA - 2015// TI - Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb JO - Proc Natl Acad Sci U S A VL - 112 UR - https://doi.org/10.1073/pnas.1506357112 DO - 10.1073/pnas.1506357112 ID - Weigelin2015 ER - TY - JOUR AU - Gauttier, V. AU - Judor, J. P. AU - Guen, V. AU - Cany, J. AU - Ferry, N. AU - Conchon, S. PY - 2014 DA - 2014// TI - Agonistic anti-CD137 antibody treatment leads to antitumor response in mice with liver cancer JO - Int J Cancer VL - 135 UR - https://doi.org/10.1002/ijc.28943 DO - 10.1002/ijc.28943 ID - Gauttier2014 ER - TY - JOUR AU - Maus, M. V. AU - Thomas, A. K. AU - Leonard, D. G. AU - Allman, D. AU - Addya, K. AU - Schlienger, K. PY - 2002 DA - 2002// TI - Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB JO - Nat Biotechnol VL - 20 UR - https://doi.org/10.1038/nbt0202-143 DO - 10.1038/nbt0202-143 ID - Maus2002 ER - TY - JOUR AU - Bagheri, S. AU - Yousefi, M. AU - Safaie Qamsari, E. AU - Riazi-Rad, F. AU - Abolhassani, M. AU - Younesi, V. PY - 2017 DA - 2017// TI - Selection of single chain antibody fragments binding to the extracellular domain of 4-1BB receptor by phage display technology JO - Tumour Biol VL - 39 ID - Bagheri2017 ER - TY - JOUR AU - Kim, Y. J. AU - Brutkiewicz, R. R. AU - Broxmeyer, H. E. PY - 2002 DA - 2002// TI - Role of 4-1BB (CD137) in the functional activation of cord blood CD28− CD8+ T cells JO - Blood. VL - 100 UR - https://doi.org/10.1182/blood-2001-11-0136 DO - 10.1182/blood-2001-11-0136 ID - Kim2002 ER - TY - JOUR AU - Margina, D. AU - Ilie, M. AU - Manda, G. AU - Neagoe, I. AU - Danciulescu-Miulescu, R. AU - Purdel, C. N. PY - 2014 DA - 2014// TI - In vitro effects of prolonged exposure to quercetin and epigallocatechin gallate of the peripheral blood mononuclear cell membrane JO - Cell Mol Biol Lett VL - 19 UR - https://doi.org/10.2478/s11658-014-0211-7 DO - 10.2478/s11658-014-0211-7 ID - Margina2014 ER - TY - JOUR AU - Daniel-Meshulam, I. AU - Horovitz-Fried, M. AU - Cohen, C. J. PY - 2013 DA - 2013// TI - Enhanced antitumor activity mediated by human 4-1BB-engineered T cells JO - Int J Cancer VL - 133 ID - Daniel-Meshulam2013 ER - TY - JOUR AU - Jin, H. B. AU - Lu, L. AU - Xie, L. AU - Yang, J. F. AU - Zhang, X. F. AU - Ma, S. L. PY - 2019 DA - 2019// TI - Concentration changes in gemcitabine and its metabolites after hyperthermia in pancreatic cancer cells assessed using RP-HPLC JO - Cell Mol Biol Lett VL - 24 UR - https://doi.org/10.1186/s11658-019-0153-1 DO - 10.1186/s11658-019-0153-1 ID - Jin2019 ER - TY - JOUR AU - Qamsari, E. S. AU - Sharifzadeh, Z. AU - Bagheri, S. AU - Riazi-Rad, F. AU - Younesi, V. AU - Abolhassani, M. PY - 2017 DA - 2017// TI - Isolation and characterization of anti c-met single chain fragment variable (scFv) antibodies JO - J Immunotoxicol VL - 14 UR - https://doi.org/10.1080/1547691X.2016.1251512 DO - 10.1080/1547691X.2016.1251512 ID - Qamsari2017 ER - TY - JOUR AU - Wen, T. AU - Bukczynski, J. AU - Watts, T. H. PY - 2002 DA - 2002// TI - 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function JO - J Immunol VL - 168 UR - https://doi.org/10.4049/jimmunol.168.10.4897 DO - 10.4049/jimmunol.168.10.4897 ID - Wen2002 ER - TY - JOUR AU - Ni, X. AU - Li, X. Z. AU - Fan, Z. R. AU - Wang, A. AU - Zhang, H. C. AU - Zhang, L. PY - 2018 DA - 2018// TI - Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats JO - Cell Mol Biol Lett VL - 23 UR - https://doi.org/10.1186/s11658-018-0106-0 DO - 10.1186/s11658-018-0106-0 ID - Ni2018 ER - TY - JOUR AU - Rosenberg, S. A. PY - 2011 DA - 2011// TI - Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know JO - Nat Rev Clin Oncol VL - 8 UR - https://doi.org/10.1038/nrclinonc.2011.116 DO - 10.1038/nrclinonc.2011.116 ID - Rosenberg2011 ER - TY - JOUR AU - June, C. H. PY - 2007 DA - 2007// TI - Adoptive T cell therapy for cancer in the clinic JO - J Clin Invest VL - 117 UR - https://doi.org/10.1172/JCI32446 DO - 10.1172/JCI32446 ID - June2007 ER - TY - JOUR AU - Jena, B. AU - Dotti, G. AU - Cooper, L. J. PY - 2010 DA - 2010// TI - Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor JO - Blood. VL - 116 UR - https://doi.org/10.1182/blood-2010-01-043737 DO - 10.1182/blood-2010-01-043737 ID - Jena2010 ER - TY - JOUR AU - Johnson, L. A. AU - Morgan, R. A. AU - Dudley, M. E. AU - Cassard, L. AU - Yang, J. C. AU - Hughes, M. S. PY - 2009 DA - 2009// TI - Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen JO - Blood. VL - 114 UR - https://doi.org/10.1182/blood-2009-03-211714 DO - 10.1182/blood-2009-03-211714 ID - Johnson2009 ER - TY - JOUR AU - Cooper, D. AU - Bansal-Pakala, P. AU - Croft, M. PY - 2002 DA - 2002// TI - 4–1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity JO - Eur J Immunol VL - 32 UR - https://doi.org/3.0.CO;2-X DO - 3.0.CO;2-X ID - Cooper2002 ER - TY - JOUR AU - Shuford, W. W. AU - Klussman, K. AU - Tritchler, D. D. AU - Loo, D. T. AU - Chalupny, J. AU - Siadak, A. W. PY - 1997 DA - 1997// TI - 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses JO - J Exp Med VL - 186 UR - https://doi.org/10.1084/jem.186.1.47 DO - 10.1084/jem.186.1.47 ID - Shuford1997 ER - TY - JOUR AU - Dudley, M. E. AU - Wunderlich, J. R. AU - Robbins, P. F. AU - Yang, J. C. AU - Hwu, P. AU - Schwartzentruber, D. J. PY - 2002 DA - 2002// TI - Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes JO - Science. VL - 298 UR - https://doi.org/10.1126/science.1076514 DO - 10.1126/science.1076514 ID - Dudley2002 ER - TY - JOUR AU - Chan, F. K. PY - 2007 DA - 2007// TI - Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling JO - Cytokine. VL - 37 UR - https://doi.org/10.1016/j.cyto.2007.03.005 DO - 10.1016/j.cyto.2007.03.005 ID - Chan2007 ER - TY - JOUR AU - Son, J. H. AU - Lee, U. H. AU - Lee, J. J. AU - Kwon, B. AU - Kwon, B. S. AU - Park, J. W. PY - 2004 DA - 2004// TI - Humanization of agonistic anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial library JO - J Immunol Methods VL - 286 UR - https://doi.org/10.1016/j.jim.2004.01.006 DO - 10.1016/j.jim.2004.01.006 ID - Son2004 ER - TY - JOUR AU - Compte, M. AU - Harwood, S. L. AU - Muñoz, I. G. AU - Navarro, R. AU - Zonca, M. AU - Perez-Chacon, G. PY - 2018 DA - 2018// TI - A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity JO - Nat Commun VL - 9 UR - https://doi.org/10.1038/s41467-018-07195-w DO - 10.1038/s41467-018-07195-w ID - Compte2018 ER - TY - JOUR AU - Lei, G. AU - Xu, M. AU - Xu, Z. AU - Gu, L. AU - Lu, C. AU - Bai, Z. PY - 2017 DA - 2017// TI - A novel fully human agonistic single chain fragment variable antibody targeting death receptor 5 with potent antitumor activity in vitro and in vivo JO - Int J Mol Sci VL - 18 UR - https://doi.org/10.3390/ijms18102064 DO - 10.3390/ijms18102064 ID - Lei2017 ER - TY - JOUR AU - Park, K. J. AU - Lee, S. H. AU - Kim, T. I. AU - Lee, H. W. AU - Lee, C. H. AU - Kim, E. H. PY - 2007 DA - 2007// TI - A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-06-4766 DO - 10.1158/0008-5472.CAN-06-4766 ID - Park2007 ER - TY - JOUR AU - Lu, L. AU - Wang, X. AU - Zhang, A. AU - Huang, F. AU - Yan, Y. AU - Li, W. PY - 2019 DA - 2019// TI - Selection and expression of CD40 single chain variable fragment by phage display and evaluation of tumor specific immune activation JO - Int Immunopharmacol VL - 71 UR - https://doi.org/10.1016/j.intimp.2019.03.020 DO - 10.1016/j.intimp.2019.03.020 ID - Lu2019 ER - TY - JOUR AU - Gilbreth, R. N. AU - Oganesyan, V. Y. AU - Amdouni, H. AU - Novarra, S. AU - Grinberg, L. AU - Barnes, A. PY - 2018 DA - 2018// TI - Crystal structure of the human 4-1BB/4-1BBL complex JO - J Biol Chem VL - 293 UR - https://doi.org/10.1074/jbc.RA118.002803 DO - 10.1074/jbc.RA118.002803 ID - Gilbreth2018 ER - TY - JOUR AU - Bitra, A. AU - Doukov, T. AU - Croft, M. AU - Zajonc, D. M. PY - 2018 DA - 2018// TI - Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier JO - J Biol Chem VL - 293 UR - https://doi.org/10.1074/jbc.RA118.003176 DO - 10.1074/jbc.RA118.003176 ID - Bitra2018 ER - TY - JOUR AU - Li, Y. AU - Tan, S. AU - Zhang, C. AU - Chai, Y. AU - He, M. AU - Zhang, C. W. PY - 2018 DA - 2018// TI - Limited cross-linking of 4-1BB by 4-1BB ligand and the agonist monoclonal antibody Utomilumab JO - Cell Rep VL - 25 UR - https://doi.org/10.1016/j.celrep.2018.09.073 DO - 10.1016/j.celrep.2018.09.073 ID - Li2018 ER -