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Table 1 Electrical membrane potentials and pH for selected organelles and their effect on the local ascorbate concentration assuming that its concentration in the cytoplasm equals 1 mM [6, 33, 37,38,39,40,41,42]

From: On the physiological and cellular homeostasis of ascorbate

Membrane Membrane potential pH \( {\boldsymbol{C}}_{\boldsymbol{asc}}^{\boldsymbol{el}}\left[\boldsymbol{mM}\right] \)a \( {\boldsymbol{C}}_{\boldsymbol{asc}}^{\boldsymbol{pH}}\left[\boldsymbol{mM}\right] \)a
Lysosome +  20 mV 5 2.2 0,006
Endosome +  70 mV 7 9 1
Mitochondria (−150 mV) - (−  180 mV) 8 0.003 6.3
Golgi +  30 mV 6–6.7 3.2 0,2
Nucleus + 3 0 mV 7.2 3.2 1
  1. aThe hypothetical ascorbate concentration was calculated for a single factor pH or electrical membrane potential,\( {C}_{asc}^{pH}\left[ mM\right]\ \mathrm{and}\ {C}_{asc}^{el}\left[ mM\right] \), respectively