TY - JOUR AU - Forkasiewicz, Agata AU - Dorociak, Maja AU - Stach, Kamilla AU - Szelachowski, Piotr AU - Tabola, Renata AU - Augoff, Katarzyna PY - 2020 DA - 2020/06/09 TI - The usefulness of lactate dehydrogenase measurements in current oncological practice JO - Cellular & Molecular Biology Letters SP - 35 VL - 25 IS - 1 AB - One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), which regulates the processing of glucose to lactic acid. As serum LDH levels were found to be commonly increased in cancer patients and correlated with poor clinical outcome and resistance to therapy, the determination of LDH has become a standard supportive tool in diagnosing cancers or monitoring the effects of cancer treatment. SN - 1689-1392 UR - https://doi.org/10.1186/s11658-020-00228-7 DO - 10.1186/s11658-020-00228-7 ID - Forkasiewicz2020 ER -