Fig. 4

miR-3619-5p is a direct binding target of LINC00665. a The relationships of miR-3619-5p, miR-761, and miR-296-3p expression with poor patient prognosis were analyzed using the Kaplan–Meier plotter (http://kmplot.com/analysis/index.php). b miR-3619-5p expression levels in breast cancer (BC) tissues. c Relationship between expression levels of LINC00665 and miR-3619-5p. d miR-3619-5p expression levels in BC cells. e miR-3619-5p expression levels in BC cells after LINC00665 was knocked down by transfecting cells with the si-LINC00665 plasmid. f Potential binding sites between LINC00665 and miR-3619-5p, as predicted using the LncBase Predicted v.2 website. g and h Luciferase reporter assays showing that LINC00665 has a direct binding site for miR-3619-5p. ***P < 0.001